“The SNO Annual Meeting is the largest annual conference focused on neuro-oncology and an ideal forum for sharing new data on the use of immunotherapy and TTFields therapy in the treatment of GBM as well as our largest real-world study to date and additional insights about the safety and efficacy of TTFields therapy,” said Frank Leonard, President of Novocure’s U.
Se interessou? Então corra para garantir o seu NervoCure no sitio oficial do fabricante. Lá você encontra descontos especiais e a garantia do manter-se adquirindo um Resultado original e de habilidade.
The TTFields treatment modality is the brainchild of Professor Yoram Palti (Professor Emeritus of Physiology and Biophysics at the Technion Israel Institute of Technology in Haifa, Israel) who hypothesized that alternating electric fields in the intermediate frequency range could disrupt cancer cell division and cause cancer cell death. Professor Palti rationalized that electric fields within the frequency range of 100–300 kHz would penetrate rapidly dividing cancer cells and disrupt essential processes and cellular structures leading to apoptotic cell death. To test his hypothesis, Professor Palti set up a home laboratory, where he successfully demonstrated that when applied at tumour cell-specific frequencies (200 kHz for GBM), alternating electric fields disrupt cell division, leading to cancer cell death but sparing healthy cells.
Learn more about our company and our mission through stories about patients, our colleagues, our collaborators and our culture.
NovoCure has not confirmed its next earnings publication date, but the company's estimated earnings date is Thursday, July 25th, 2024 based off last year's report dates. Learn more on NVCR's earnings history.
TTFields are low intensity, intermediate frequency alternating electric fields that act upon rapidly dividing glioma and other cancer cells2,3 especially during metaphase, anaphase and telophase of mitotic cell division. When an alternating electric field is generated across a cancer cell, charged molecules within the cell will move back and forth and dipolar molecules will rotate. At sufficiently high frequencies, the motility of such molecules diminishes. Molecules with a high electrical dipole moment such as tubulin dimers and septins are therefore forced to align with the direction of the alternating electric fields (TTFields) under a uniform field distribution, nervocure which is generated in cells during metaphase. This disrupts microtubule spindle formation and septin fibres localization during metaphase, leading to mitotic catastrophe, which may culminate in mitotic cell death.
Your browser isn’t supported anymore. Update it to get the best YouTube experience and our latest features. Learn more
The lack of systemic adverse events allows TTFields to be potentially combined with other therapeutic modalities with some assurance that TTFields treatment may offer synergistic clinical benefit with targeted treatments without compounding adverse systemic effects. Health-related quality of life (HRQoL) is a prominent concern in treating brain tumours, and the combination of TTFields with TMZ had pelo negative influence on HRQoL for GBM patients with the exception of itchy skin18, an expected consequence of the long-term application of the transducer arrays to the patient’s shaved scalp. In fact, the longer PFS observed in TTFields-treated patients was accompanied by a longer time to progression related deterioration in several important HRQoL scales.
TTFields’ unique mechanism of action underscores key points related to its effective administration and clinical benefit. Unlike chemotherapeutic agents, TTFields are only active while the arrays are affixed to the scalp and the alternating electric fields are generated between the transducer arrays. As a loco-regional and non-invasive targeted therapy, TTFields has the benefit of avoiding systemic adverse events associated with chemotherapy and targeted systemic therapies. The primary treatment-associated adverse event experienced by some patients with TTFields is skin irritation below the arrays, which is predictable and easily manageable in the majority of cases.
Many of the cells, however, will be able to proceed from metaphase to anaphase and telophase. During these phases, the dividing cell assumes an hourglass shape as it begins to split into two distinct daughter cells, causing a non-uniform alternating electric field. This non-uniform field causes polarized cellular components to migrate towards the cleavage furrow of the two daughter cells (an effect called dielectrophoresis) and the dividing cells are unable to divide properly. Overall, the anti-mitotic effect of TTFields may ultimately lead to cell death or to the formation of abnormal dividing cells with an uneven number of chromosomes (Fig. 2).
Já ficou desesperado e isolado por causa da dor que nunca vai embora? Costuma ficar usando raiva, ansioso e triste porque nao consegue resolver este problema? Deixou de executar coisas de que você gosta por causa da dor?
TTFields therapy causes minimal damage to healthy cells. Mild to moderate skin irritation is the most common side effect reported. TTFields therapy is approved in certain countries for the treatment of adults with glioblastoma, malignant pleural mesothelioma and pleural mesothelioma, some of the most difficult cancer types to treat. The therapy shows promise in multiple solid tumor types – including some of the most aggressive forms of cancer.
Os sintomas da neuropatia facial hereditária podem vir a variar em gravidade e idade de início. Geralmente, a fraqueza facial ocorre de forma repentina e Pode vir a afetar qualquer lado do rosto.
Invista em 1 produto de habilidade comprovada e diga adeus aos problemas por hipertensão. Com este NERVOCURE, você terá a tranquilidade de manter-se cuidando bem da tua pressãeste arterial sem precisar gastar fortunas em tratamentos caros e arriscados.